研究業績
2015
2014
2013
2012
2011
2010
2009
2008
2007
2006
2005
2004
2003
2002
2001
2000
1999
- Hirota, Y., Yamashita, S., Kurihara, Y., Jin, X., Aihara, M., Saigusa, T., Kang, D., and Kanki, T.
Mitophagy is primarily due to alternative autophagy and requires the MAPK1 and MAPK14 signaling pathways.
Autophagy 11, 332-343, (2015).
Autophagy 11, 332-343, (2015).
2014
- Tashiro, K., Shishido, M., Fujimoto, K., Hirota Y., Yo, K., Gomi, T., and Tanaka, Y.
Age-related disruption of autophagy in dermal fibroblasts modulated extracellular matrix components.
Biochem. Biophys. Res. Commun. 443, 167-172, (2014).
Biochem. Biophys. Res. Commun. 443, 167-172, (2014).
- Aihara, M., Jin, X., Kurihara, Y., Yoshida, Y., Matsushima, Y., Oku, M., Hirota, Y., Saigusa, T., Aoki, Y., Uchiumi, T., Yamamoto, T., Sakai, Y., Kang, D., and Kanki, T.
The Tor and Sin3-Rpd3 complex regulate expression of the mitophagy receptor protein Atg32.
J. Cell Sci. 127, 3184-3196, (2014).
J. Cell Sci. 127, 3184-3196, (2014).
- Hideaki Fujita, Jose C.J.M.D.S. Menezes, Sergio M. Santos, Sadaki, Yokota, Shrivallabh P. Kamat, Jose A.S. Cavaleiro, Tomonori Motokawa, Tomomi Kato, Mayu Mochizuki, Toshiyuki Fujiwara, Yuki Fujii, and Yoshitaka Tanaka.
Inulavosin and its
benzo-derivatives, melanogenesis inhibitors, target the copper loading
mechanism to the active site of tyrosinase.
Pigment Cell Melanoma Res. 27, 376-386, (2014).
Pigment Cell Melanoma Res. 27, 376-386, (2014).
2013
- Fujita, H., Iwabu, Y., Tokunaga, K., and Tanaka, Y.
Membrane-associated RING-CH (MARCH) 8 mediates the ubiquitination and lysosomal degradation of the transferrin receptor.
J. Cell Sci. 126, 2798-2809, (2013).
J. Cell Sci. 126, 2798-2809, (2013).
- Ogi, S., Fujita, H., Kashihara, M., Yamamoto, C.,
Sonoda, K., Okamoto, I., Nakagawa, K., Ohdo, S., Tanaka Y., Kuwano, M.,
Ono, M.
Sorting nexin 2-mediated membrane trafficking of c-Met contributes to sensitivity of molecular-targeted drugs.
Cancer Sci. 104, 573-583, (2013).
Cancer Sci. 104, 573-583, (2013).
- Kanki, T., Kurihara, Y., Jin, X., Goda, T., Ono, Y.,
Aihara, M., Hirota Y., Saigusa, T., Aoki, Y., Uchiumi, T., and Kang, D.
Casein kinase 2 is essential for mitophagy.
EMBO Rep. 14, 788-794, (2013).
2012
- Fujita, H., Fujimoto, K., and Tanaka, Y.
Intracellular logistics of BST2/tetherin
Curr. HIV Res. 10, 321-326, (2012).
Curr. HIV Res. 10, 321-326, (2012).
- Toyomitsu, E., Tsuda, M., Yamashita, T., Tozaki-Saitoh, H., Tanaka, Y., and Inoue, K.
CCL2 promotes P2X4 receptor trafficking to the cell surface of microglia.
Purinergic Signal. 8, 301-310, (2012).
Purinergic Signal. 8, 301-310, (2012).
- Kurihara, Y., Kanki, T., Aoki, Y., Hirota Y., Saigusa, T., Uchiumi, T., and Kang, D.
Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeast.
J. Biol. Chem. 287, 3265-3272, (2012).
- Hirota, Y., Kang, D., and Kanki, T.
The physiological role of mitophagy: new insights into phosphorylation events.
Int. J. Cell Biol. 2012, ID;354914, 2012
2011
- Tachiyama, R., Ishikawa, D., Matsumoto, M., Nakayama,
K., Yoshimori, T., Yokota, S., Himeno, M., Tanaka, Y., and
Fujita, H.
Proteome of ubiquitin/MVB-Pathway: Possible involvement
of Iron-induced ubiquitylation of transferrin receptor in lysosomal
degradation.
Genes to Cells 16, 448-466, (2011).
Genes to Cells 16, 448-466, (2011).
- Aoki, Y., Kanki, T., Hirota, Y., Kurihara, Y., Saigusa, T., Uchiumi, T., and Kang, D.
Phosphorylation of Serine 114 on Atg32 mediates mitophagy.
Mol. Biol. Cell 22, 3206-3217, (2011).
2010
- Fujita, H., Hongo, M., Mochizuki, M., Yokoyama, K., and Tanaka, Y.
Inhibitory effects of
16-hydroxy-9-oxo-10E,12E,14E-octadecatrienoic acid (Corchorifatty acid
B) isolated from Melissa officinalis Linne on melanogenesis.
Exp. Dermatol. 20, 420-424, (2010).
Exp. Dermatol. 20, 420-424, (2010).
- Amano, J., Masuyama, N., Hirota, Y., Tanaka,
Y., Igawa, Y., Shiokawa, R., Okutani, T., Miyayama, T., Nanami, M., and
Ishigai, M.
Antigen-dependent
Internalization is related to Rapid Elimination from Plasma of
Humanized Anti-HM1.24 Monoclonal Antibody (AHM).
Drug Metab. Dispos. 38, 2339-2346. (2010).
Drug Metab. Dispos. 38, 2339-2346. (2010).
- Iwabu, Y., Kinomoto, M., Tatsumi, M., Fujita,
H., Shimura, M., Tanaka, Y., Ishizaka, Y., Nolan, D., Mallal, S., Sata,
T., and Tokunaga, K.
Differential Anti-APOBEC3G Activity of HIV-1 Vif Proteins Derived from Different Subtypes.
J. Biol. Chem. 285, 35350-35358 (2010).
J. Biol. Chem. 285, 35350-35358 (2010).
- Iwabu, Y., Fujita, H., Tanaka, Y., Sata, T., and Tokunaga, K.
Direct internalization of cell-surface BST-2/tetherin by HIV-1 accessory protein Vpu.
Commun. Integr. Biol., 3, 366-369 (2010).
Commun. Integr. Biol., 3, 366-369 (2010).
- Ozono, C., Etoh, S., Matsumoto, M., Nakayama, K., Hirota, Y., Tanaka, Y., Fujita, H.
Nedd4-interacting protein
2, a short half-life membrane protein degraded in lysosomes, negatively
controls down-regulation of connexin43.
Biol. Pharm. Bull. 33, 951-957, (2010).
Biol. Pharm. Bull. 33, 951-957, (2010).
2009
- Iwabu, Y., Fujita, H., Kinomoto, M., Kaneko, K., Ishizawa, Y., Tanaka, Y., Sata, T., and Tokunaga, K.
HIV-accessory protein Vpu internalizes cell surface BST-2/tetherin through transmembrane interactions leading to lysosomes.
J. Biol. Chem. 284, 35060-35072 (2009).
J. Biol. Chem. 284, 35060-35072 (2009).
- Hirota, Y., and Tanaka, Y.
A small GTPase, human Rab32, is required for the formation of autophagic vacuoles under basal conditions.
Mol. Cell Life Sci. 66, 2913-2932 (2009).
Mol. Cell Life Sci. 66, 2913-2932 (2009).
- Masuyama, N., Kuronita, T., Tanaka, R., Muto,
T., Hirota, Y., Takigawa, A., Fujita, H., Aso, Y., Amano, J., and
Tanaka, Y.
HM1.24 is inetrnalized from lipid rafts by clathrin-mediated endocytosis through interaction with alpha-adaptin.
J. Biol. Chem. 284, 15927-15941 (2009).
J. Biol. Chem. 284, 15927-15941 (2009).
- Kashiwayama, Y., Seki, M., Yasui, A.,
Murasaki, Y., Morita, M., Yamashita, Y., Sakaguchi, M., Tanaka, Y., and
Imanaka, T.
70-kDa peroxisomal
membrane protein related protein (P70R/ABCD4) localizes to endoplasmic
reticulum not peroxisomes, and NH2-terminal hydrophobic property
determines the subcellular location of ABC subfamily D proteins.
Exp. Cell Res. 315, 190-205 (2009).
Exp. Cell Res. 315, 190-205 (2009).
- Fujita, H., Motokawa, T., Katagiri, T., Yokota, S., Yamamoto, A., Himeno, M., and Tanaka, Y.
Inulavosin, a novel melanogenesis inhibitor, leads t mistargeting of tyrosinase to lysosomes and accelerates its degradation.
J. Invest. Derm. 129, 1489-1499 (2009).
J. Invest. Derm. 129, 1489-1499 (2009).
2008
- Ikeda, K., Hirayama, M., Hirota, Y., Asa, E., Seki, J., and Tanaka, Y.
Drug-induced phospholipidpsis is caused by blockade of mannose 6-phosphate receptor-mediated targeting of lysosomal enzymes.
Biochem. Biophys. Res. Commun. 377, 268-274 (2008).
Biochem. Biophys. Res. Commun. 377, 268-274 (2008).
- Ishida, T., Kawakami, M., Baba, H., Yahata,
M., Mutoh, J., Takeda, S., Fujita, H., Tanaka, Y., Ishii, Y., and
Yamada, H.
Proteasome affects the expression of aryl hydrocarbon receptor-regulated proteins.
Toxicol. Pharmacol. 26, 348-354 (2008).
Toxicol. Pharmacol. 26, 348-354 (2008).
2007
- Hirota, Y., Kuronita, T., Fujita, H., and Tanaka, Y.
A role fo Rab5 activity in the biogenesis of endosomal and lysosomal compartments.
Biochem. Biophys. Res. Commun. 364, 40-47 (2007).
Biochem. Biophys. Res. Commun. 364, 40-47 (2007).
2006
- Zhang, J., Fujii, S., Wu, Z., Hashioka, S., Tanaka, Y., Shiratsuchi, A., Nakanishi, Y., and Nakanishi, H.
Involvement of COX-1 and
up-regulated prostaglandin E synthases in phosphatidylserine
liposome-induced prostaglandin E2 production by microglia.
J. Neuroimmunol. 172, 112-120 (2006).
J. Neuroimmunol. 172, 112-120 (2006).
2005
- Kuronita, T., Hatano, T., Furuyama, A.,
Hirota, Y., Masuyama, N., Safitg, P., Himeno, M., Fujita, H., and
Tanaka, Y.
The NH2-terminal transmembrane and lumenal domains of LGP85 are needed for the formation of enlarged endosomes/lysosomes.
Traffic 6, 895-906 (2005).
Traffic 6, 895-906 (2005).
- Nomura, H., Furuta, A., Tanaka, Y., and Iwaki, T.
Forced retraction of spinal root injury enhances activation of p38 MAPK cascade in infiltrating macrophages.
Neuropathology 25, 37-47 (2005).
Neuropathology 25, 37-47 (2005).
2004
- Eskelinen, E.-L., Schmidt, C. K., Neu, S.,
Willenborg, M., Fuertes, G., Salvador, N., Tanaka, Y., Lullmann-Rauch,
R., Hartmann, D., Heeren, J., von Figura, K., Knecht, E., and Saftig,
P.
Distributed cholesterol traffic but normal proteolztic function in LAMP-1/LAMP-2 double-deficient fibroblasts.
Mol. Biol. Cell 15, 3132-3145 (2004).
Mol. Biol. Cell 15, 3132-3145 (2004).
- Hirosako, K., Imasato, H., Hirota, Y.,
Kuronita, T., Masuyama, N., Nishioka, M., Umeda, A., Fujita, H.,
Himeno, M., and Tanaka, Y.
3-Methyladenine
specifically inhibits retrograde transport of cation-independent
mannose 6-phosphate/insulin-like growth factor II receptor from the
early endosome to the TGN.
Biochem. Biophys. Res. Commun. 316, 845-852 (2004).
Biochem. Biophys. Res. Commun. 316, 845-852 (2004).
- Fujita, H., Umezuki, Y., Ishikawa, D.,
Uchimura, S., Imamura, K., Nara, A., Yoshimori, T., Hayashizaki, Y.,
Kawai, J., Ishido, K., Tanaka, Y., and Himeno, M.
Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B.
J. Cell Sci. 117, 2997-3009 (2004).
J. Cell Sci. 117, 2997-3009 (2004).
- Ohnishi. H., Mizunoe, Y., Takade, A., Tanaka, Y., Miyamoto, H., Harada, M., and Yoshida, S.
Legionella dumoffii DjlA, a member of the DnaJ family, is required for intracellular growth.
Infect. immun. 72, 3592-3603 (2004).
Infect. immun. 72, 3592-3603 (2004).
- Hirota, Y., Masuyama, N., Kuronita, T., Fujita, H., Himeno, M., and Tanaka, Y.
Analysis of post-lysosomeal compartment.
Biochem. Biophys. Res. Commun. 314, 306-312 (2004).
Biochem. Biophys. Res. Commun. 314, 306-312 (2004).
2003
- Umeda, A., Fujita, H., Kuronita, T., Hirosako, K., Himeno, M., and Tanaka, Y.
Distribution and
trafficking of MPR300 is normal in cells with cholesterol accumulated
in late endocytic compartments: evidence for early endosome-to-TGN
trafficking of MPR300.
J. Lipid Res. 44, 1821-1832 (2003).
J. Lipid Res. 44, 1821-1832 (2003).
- Gamp, A. C.*, Tanaka, Y.*, Lullmann-Rauch, R.,
Wittke, D., D'Hooge, R., De Deyn, P. P., Moser, T., Maier, H.,
Hartmann, D., Reiss, K., Illert, A. -L., von Figura, K., and Saftig, P.
LIMP-2/LGP85 deficiency caauses ureteric pelvic junction obstruction, deafness and peripheral neuropathy.
Hum. Mol. Genet. 12, 631-646 (2003). (*equally contributed)
Hum. Mol. Genet. 12, 631-646 (2003). (*equally contributed)
- Niwa, K., Tanaka, R., Murase, H., Ishikawa, T., Fujita, H., Himeno, M., and Tanaka, Y.
Two lysosomal membrane
proteins, LGP85 and LGP107, are delivered to late endosomes/lysosomes
through different intracellular routes after exiting from the
trans-Golgi network.
Biochem. Biophys. Res. Commun. 301, 833-840 (2003).
Biochem. Biophys. Res. Commun. 301, 833-840 (2003).
- Eskelinen, E.-L., Tanaka, Y., and Saftig, P.
At the acidic edge: emerging functions for lysosomal membrane proteins.
Trends Cell Biol. 13, 137-145 (2003).
Trends Cell Biol. 13, 137-145 (2003).
- Fujita, H., Yamanaka, M., Imamura, K., Tanaka, Y., Nara, A., Yoshimori, T., Yokota, S., and Himeno, M.
A dominant negative from
of the AAA ATPase SKD1/VPS4 impairs membrane trafficking out of
endosomal/lysosomal compartments: Class E vps phenotype in mammalian
cells.
J. Cell Sci. 116, 401-414 (2003).
J. Cell Sci. 116, 401-414 (2003).
2002
- Kuronita, T., Eskelinen, E.-L., Fujita, H., Saftig, P., Himeno, M., and Tanaka, Y. A role for the lysosomal membrane protein LGP85 in the biogenesis and maintenance of endosomal and lysosomal morphology. J. Cell Sci. 115, 4117-4131 (2002).
- Eskelinen, E.-L., Illert, A. -L., Tanaka, Y., Schwarzmann, G., Blanz, J., von Figura, K., and Saftig, P. Role of LAMP-2 in lysosome biogenesis and autophagy. Mol. Biol. Cell 13, 3355-3368 (2002).
2001
- Saftig, P., Tanaka, Y., Lullmann-Rauch, R., and von Figura, K.
Disease model: LAMP-2 enlightens Danon disease.
Trends Mol. Med. 7, 37-38 (2001).
Trends Mol. Med. 7, 37-38 (2001).
- Fujita, H., Sasano, E., Yasunaga, K., Furuta, K., Yokota, S., Wada, I., and Himeno, M.
Evedence for distinct membrane traffic pathways to melanosomes and lysosomes in melanocytes.
J. Investig. Dermatol. Symp. Proc. 6, 19-24 (2001).
J. Investig. Dermatol. Symp. Proc. 6, 19-24 (2001).
2000
- Tanaka, Y., Guhde, G., Suter, A., Eskelinen,
E.-L., Hartmenn, D., Lullmann-Rauch, R., Janssen, P.M.L., Blanz, J.,
von Figura, K., and Saftig, P.
Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2 deficient mice.
Nature 406, 902-906 (2000).
Nature 406, 902-906 (2000).
- Tanaka, Y., Tanaka, R., Kawabata, T., Noguchi, Y., and Himeno, M.
Lysosomal cystein
protease, cathepsin B, is targeted to lysosomes by the mannose
6-phosphate-independent pathway in rat hepatocytes: Site-specific
phosphorylation in oligosaccharides of the proregion.
J. Biochem. 128, 39-48 (2000).
J. Biochem. 128, 39-48 (2000).
- Tanaka, Y., Tanaka, R., and Himeno, M.
Lysosomal cysteine
protease, cathepsin H, is targeted to lysosomes by the mannose
6-phosphate-independent system in rat hepatocytes.
Biol. Pharm. Bull. 23, 805-809 (2000).
Biol. Pharm. Bull. 23, 805-809 (2000).
- Harada, M., Sakisaka, S., Terada, K., Kimura,
R., Kawaguchi, T., Koga, H., Taniguchi, E., Sasatomi, K., Miura, N.,
Suganuma, T., Fujita, H., Furuta, K., Tanikawa, K., Sugiyama, T., and
Sata, M.
Role of ATP7B in biliary copper excretion in a human hepatoma cell line and normal rat hepatocytes.
Gastroenterology 118, 921-928 (2000).
Gastroenterology 118, 921-928 (2000).
1999
- Alvarez, C., Fujita, H., Hubbard, A.L., and Sztul, E.
ER to Golgi transport: reqirement for p115 at a pre-Golgi VTC stage.
J. Cell Biol. 147, 1205-1221 (1999).
J. Cell Biol. 147, 1205-1221 (1999).
- Chi, S., Kitanaka, C., Noguchi, K., Mochizuki,
T., Nogashima, Y., Shirouzu, M., Fujita, H., Yoshida, M., Chen, W.,
Asai, A., Himeno, M., Yokoyama, S., and Kuchino, Y.
Oncogenic Ras triggers cell suicide through the activation of a caspase independent cell death program in human cancer.
Oncogene 18, 2281--2290 (1999).
Oncogene 18, 2281--2290 (1999).
- Fujita, H., Saeki, M., Yasunaga, K., Ueda, T., Imoto, T., and Himeno, M.
In vitro binding study of adaptor protein complex (AP-1) to lysosomal targeting motif (LI-motif).
Biochem. Biophys. Res. Commun. 255, 54-58 (1999).
Biochem. Biophys. Res. Commun. 255, 54-58 (1999).
- Andrejewski, N.,
Punnonen, E.-L., Guhde, G., Tanaka, Y., Lullmann-Rauch, R., Hartmann,
D., von Figura, K., and Saftig, P.
Normal lysosomal morphology and function in Lysosomal-Associated-Protein-Type-1 (LAMP-1) deficient mice.
J. Biol. Chem. 274, 12692-12701 (1999).
J. Biol. Chem. 274, 12692-12701 (1999).